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284 A similar phenomenon has been observed in Gln-dependent clear cell renal carcinoma (RCC), which competitively depletes environmental Gln, causing local Gln depletion and IL-23 release from tumor-infiltrating macrophages, which further activates Treg function to suppress tumor immunity

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Furthermore, the risk of developing AA is ten times higher in first-degree relatives of affected individuals

Regular sterile water lacks this protection and should only be used for single-dose preparations