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Tirzepatide vs semaglutide 1 mg in T2D SURPASS-2, HbA1c -2.01/-2.24/-2.30 pp, weight dose-responsive while HbA1c saturates: Frias NEJM 2021

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A meta-analysis of randomized controlled trials found that daily vitamin E supplementation equivalent to 25 to 536 mg/day of RRR --tocopherol for several years resulted in a significant, 10% reduction in the risk of ischemic stroke (five trials, 91,393 participants) and a nonsignificant trend towards an increased risk of hemorrhagic stroke (five trials, 100,748 participants) (120)

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