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Psychiatry 170, 290-298 (2013)

Clomiphene, a selective estrogen receptor modulator, is currently FDA-approved for treating infertility in women whose ovaries fail to produce adequate numbers of eggs.19 But doctors have begun prescribing it off-label for use in men with low testosterone after a series of clinical studies showed it to be both safe and effective as a testosterone booster

Future efforts should focus on developing biomaterial-based delivery vectors, combined with local delivery approaches like intratracheal instillation

Without proper testing, a product may appear successful during the sampling phase but develop issues once it has been stored for several months under real-world conditions