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doi: 10.2337/diabetes.51.8.2441

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Why the dual mechanism matters for research The co-activation of GIP and GLP-1 pathways produces effects that neither pathway achieves alone

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)