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In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate

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10 A note on estradiol vs estriol vs conjugated equine estrogens Though estradiol is the predominant estrogen used for control of vasomotor symptoms in menopausal and postmenopausal women it is sometimes used in combination with other estrogens such as estriol or conjugated equine estrogen products, such as Premarin, are sometimes used in place of estradiol

doi: 10.1080/21565562.2015.1009313