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Neuroglial changes in physiological brain ageing are relatively subtle, with white matter being the most affected: in healthy old age, white matter volume is decreased by ~ 10%, whereas the grey matter is reduced by a mere 3%

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In contrast, CDH2, which is typically absent in epithelial tissues, is upregulated during EMT and facilitates dynamic interactions with the extracellular matrix, thereby supporting cytoskeletal remodeling and directional migration

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