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Glutathione itself neutralizes free radicals, recycles antioxidants, is involved in phase 1 and 2 detoxification, helps transport mercury out of the cells and the brain, regulates cell growth, and is vital to mitochondrial and DNA health

However, the nonenzymatic formation of roGFP(S 2 ) from roGFP2(SSG) also proceeds extremely rapidly and competes with the final enzyme-catalyzed reaction step with implications for redox measurements as outlined below

Furthermore, elevated MCP-1 levels as a result of chemokine upregulation associated with neuroinflammatory diseases have been shown to be associated with increased BBB permeability, which can further exacerbate disease progression [26]