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Since their initial approval in the early 2000 s, the pharmacotherapy of GLP-1 RAs has been well recognized not only for achieving glycemic targets but also for their effectiveness in promoting satiety and weight loss, as well as their association with reductions in cardiovascular risk and all-cause mortality

Stress is defined as a biological response to perceived environmental or physiological threats that disrupt the homeostasis of an animal

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Patients and providers should treat them as directional rather than definitive, and decisions about participating in trials or accessing investigational therapies should always involve a specialist in endocrinology or metabolic medicine