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Most patients report mild discomfort

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

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One of the most common side effects of GLP-1 regimens is dry mouths: and therefore youre seeing a new surge in hydrating and refreshing beverages, notes Ananda Roy, senior vice president and industry advisor, consumer goods, at Circana