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A more comprehensive understanding of the molecular networks governing ferroptosis in OA will facilitate the development of refined therapeutic strategies at multiple levels, potentially leading to improved structural and functional outcomes for patients

In summary, beneficial Clostridium and their metabolites exert multifaceted protective effects in eight major ADs by regulating gut-immune crosstalk, reinforcing intestinal barrier integrity, and alleviating disease-specific pathological damage, holding great promise as a complementary strategy for clinical immunotherapy

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