A gradual increase in dosage beginning at 2 mg and escalating every four weeks helps reduce side effects while enhancing the researchs effectiveness
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Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]
Neither outcome is acceptable in controlled research