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Upon activation, free radicals such as nitric oxide (NO) and superoxide are released, which elevates oxidative stress contributing to pathogen elimination and local tissue damage ( Migraine Pathogenesis: Role of Oxidative Stress, Neuroinflammation, and Mitochondrial Dysfunction Migraine is defined as a neurovascular disorder involving cortical spreading depression (CSD), neurogenic inflammation, and dysfunction in cranial vascular contractility ( Oxidative Stress Oxidative stress role in migraine pathogenesis is emphasized by multiple studies

When your B12 is low, you might feel: Tired all the time, even after sleeping well Mentally foggy, with trouble concentrating Dizzy or lightheaded Depressed or anxious Your energy drops, and basic tasks can start to feel overwhelming

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