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For more information about FDAs posting of comments to public dockets, see 80 FR 56469, September 18, 2015, or access the information at: Federal Register/Vol

However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2

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