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The primary effects of GLP-1 RA involve controlling blood glucose levels in individuals with T2DM by promoting glucose-dependent insulin release [67], inhibiting glucagon production, decreasing hepatic glucose output [68], improving insulin secretion, reducing the apoptosis of -cells, promoting the proliferation of -cells [69] and curbing weight gain [70]

Alcohol should be minimised during retatrutide treatment as it can worsen nausea, impair blood glucose regulation, and increase the risk of hypoglycaemia in people also taking insulin or sulfonylureas

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It may be best to avoid the Wolverine stack in certain scenarios