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Separating the effects of the medication from the effects of the underlying disease is something researchers are still actively working through

Lancet 2010;375:22342243 [DOI] [PubMed] [Google Scholar] 131

Adverse events data management Adverse events were elicited systematically via a full review of systems at the time of each visit, and parents were instructed to immediately report symptoms or illnesses occurring between visits via telephone

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