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Separate studies delved directly into the brain to look for tell-tale signs with bi-polar: Postmortem studies of patients with BD revealed reduced expression of NMDAR subunit NR1 in the prefrontal cortex (44) and reduced expression of several NMDA, AMPA, and kainite receptor subunits in the medial temporal cortex Again, pointing to reduced glutamate at the NMDA receptor

Tachikawa M, Fujinawa J, Takahashi M, Kasai Y, Fukaya M, Sakai K, Yamazaki M, Tomi M, Watanabe M, Sakimura K: Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant

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