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[3] Ipamorelin was originally developed by Novo Nordisk, and was investigated in phase II clinical trials by Helsinn Therapeutics for the treatment of postoperative ileus, but was discontinued due to lack of efficacy

PGC-1 knockout dysregulates the Nrf2-dependent mitochondrial biogenesis through the PGC-1/p38/GSK3/Nrf2 cascade (Navarro et al., 2017

The epithelium The intestinal epithelium is composed of five different types of cells: enterocytes, goblet cells, enteroendocrine cell, Paneth cells, and microfold cells

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