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Technically, they're GLP-1 receptor agonists, because they work on the same cell receptors as GLP-1 to activate the same response slowing digestion, prompting insulin release, and limiting appetite

In the palmitic acid (PA)-induced ceramide synthase 6 (CERS6)-deficient HK-2 and CERS6 knockdown db/db mouse models, aggravation of DKD symptoms and renal interstitial fibrosis were found, possibly due to the interaction of CERS6-derived ceramide with PINK1 to inhibit PINK1/Parkin-mediated mitophagy, which aggravates DKD [118]

Yan Shi, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Ghrelin activation of GHS-R1a also results in activation of plasma membrane N-type Ca 2+ channels (Ca v 2.2) resulting in further increases in intracellular free Ca 2+