can glutathione cause spotting Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via depletion Analysis of the response mechanism

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The most classic example is immune checkpoint inhibitors (ICIs) (pembrolizumab and atezolizumab), which target the PD-1/PD-L1 axis and have shown clinical benefits by reactivating anti-tumor T-cell responses

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