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Weaning off tirzepatide requires the same patience and monitoring as the initial dose escalation phase

Somatostatin, secreted from pancreatic -cells, acts as an inhibitory paracrine to suppress glucagon release from pancreatic -cells, and specific blockade of SSRT2 eliminates the inhibitory effect of GLP-1 on glucagon secretion

Louis, MO) and Aprotinin (500 KIU/ml, Sigma Aldrich, St