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Reported or theoretically plausible side effects of CJC 1295 and ipamorelin include: Water retention and peripheral oedema Flushing, headache, and dizziness, particularly after injection Tingling or numbness in the extremities Elevated IGF-1 levels, which over time may theoretically increase the risk of certain cancers, though a direct causal link has not been established in clinical studies [13] [14] Impaired glucose tolerance or insulin resistance GH excess and GH secretagogues are more commonly associated with raised blood glucose rather than hypoglycaemia

Other metal chelators do not exert any influence on mast cell function [186]

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Obesity, binge eating, and metabolic syndrome frequently coexist with anxiety, depression, and chronic stress, yet most metabolic therapies target peripheral pathways while neglecting central drivers of behavior