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Orforglipron also produced significant but somewhat lower weight loss than oral semaglutide

Regulatory authorities control the safety, efficacy, and manufacturing processes of the approved drugs

Clinical Pharmacokinetics, 60 (10), 13351348

All trials analyzed the composite of 3 major adverse cardiovascular events (MACE), which included cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke, except the lixisenatide study that considered 4-point MACE, which also included hospitalization for heart failure (Table 1).5764 Although all the studies with arGLP-1 have demonstrated cardiovascular safety (noninferiority vs