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TGF-1 could also induce adult mouse hepatocytes to undergo EMT, and up to 45% of the FSP1-postive fibroblasts are derived from hepatocytes in carbon tetrachloride (CCL4)-induced fibrotic liver (94)
In all models, the following fixed covariates were entered: assigned treatment (investigational product or placebo), baseline measurement of the outcome of interest, visit (day 14 1 day or day 28 1 day), visit in interaction with treatment, period (period 1 or period 2), sex and, for MIDT outcomes, incentive level
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Even if the peptide itself retained activity, injecting it introduces infection risk that no responsible protocol tolerates
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