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Mounjaro (GLP-1 and GIP receptor agonist) is FDA-approved for the treatment of type 2 diabetes mellitus

The three main problems in relation to treatment with insulin secretagogues are Hypoglycemia Weight gain Cardiovascular risk (an open discussion to date) Contraindications for treatment with insulin secretagogues are as follows: Type 1 diabetes, pregnancy, major surgeries, infections, severe trauma, allergy predisposition, and severe hypoglycemia risks (Table 10.5)

SMILES: CC(O)=O.O=C([C@H]1[N-](C2=O)[Cu+2]([NH2]C2)[N]3=CNC=C3C1)N[C@H](C([O-])=O)CCCCN