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10.1016/j.bbrc.2009.01.003

Creutzfeldt W, Ebert R: New developments in the incretin concept

It's important to note that tirzepatide is contraindicated in patients with a personal or family history of serious hypersensitivity to tirzepatide or any of the product components

11 In one clinical trial, the secoiridoids found in gentian, which are the compound responsible for that bitter taste, demonstrated both a higher response of GLP-1 and a significantly reduced appetite, evidenced by a 30% lower energy intake over the post-lunch period