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Tirzepatide is also modified with a C20 fatty diacid side chain, which helps it bind albumin and extends its half-life to about 5 days

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6 Evidence of ADE in Coronaviruses In the first report of ADE in 1964, enhancement of the infectivity of arboviruses such as Murray Valley encephalitis virus, West Nile virus, and Japanese encephalitis virus was observed during their neutralization in the presence of chicken antisera, all of which belong to the family Flaviviridae 91 , it was found afterwards that the IgG antibodies in the sera were responsible for this enhancement 27