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c-MET inhibitors have shown promising pre-clinical and early phase clinical trial anti-tumor activity in several tumor types, although results of most phase III trials with these agents have been negative

The study was also supported in part by the Center for Life Sciences, QidongSLS Innovation Fund, the State Key Laboratory of Membrane Biology of China (to Z.Z.) and the Frontier Innovation Fund of Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies (to Z.Z