In children with PWS, those who are heterozygous or homozygous for the d3 allele are more sensitive and responsive to GH treatment, leading to a significant increase in growth compared to those who are homozygous for the full-length GHR allele (136)
The use of dietary restriction to reduce behavioral symptoms is widespread, with the most popular being the "theory of excess opioid peptides", which postulates that the consumption of gluten and casein contributes to the worsening of symptoms and a diet free of these proteins improves the clinical picture
Retatrutide has not yet been studied in a dedicated sleep apnea trial, but given its greater weight loss, the expectation is that sleep apnea improvements would be at least as significant as those seen with tirzepatide, possibly more so
Together, these compounds accelerate hepatic fat metabolism through two primary pathways: enhanced methylation (which supports detoxification and cellular energy production) and lipotropic action (mobilising fat from hepatocytes and transporting it to mitochondria for oxidation)
