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PPI use in those patients should have a clear indication and be used at the lowest dose for the least amount of time necessary.116,117 Furosemide and spironolactone are the most widely used diuretics in patients with chronic liver disease and water retention

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Liver and Lungs: GHK-Cu reversed age-related gene expression changes, restored healthier tissue function, and improved outcomes in COPD models (PMID: 24166485)