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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

That said, air bubbles do take up space in the syringe that should be occupied by medication

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GLP-1 medications reduce saliva production through direct receptor activation in salivary glands, independent of overall body hydration