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What Not to Take With Retatrutide: Interactions, Foods & Safety Retatrutide is an investigational triple incretin receptor agonist targeting GLP-1, GIP, and glucagon receptors, currently in clinical trials for obesity and type 2 diabetes

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Because these drugs block the action of Acetylcholine (ACh) at muscarinic receptors, thereby inhibiting parasympathetic activity the opposite of cholinergic (rest-and-digest) effects