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also stated that MTX-induced oxidative stress may cause glomerular and tubular damage by causing MTX accumulation in the kidney (Reference Li, Abe and Yamakawa42)

Oxidative stress in inflammation-based gastrointestinal tract diseases: challenges and opportunities

The Role of Glutathione in Cell Defense Wu G, Fang YZ, Yang S, Lupton JR, Turner ND (1 March 2004)

This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation