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Greater investment in research and surveillance will help clinicians and public health professionals make evidence-based recommendations and better protect public health. Additionally, Piatkowski calls for longitudinal population-level data on peptides to model risk typologies and detect and report harm clusters

Some individuals with certain genetic predispositions may find that lifestyle strategies alone produce meaningful weight loss, while others may benefit from medical support to optimize these pathways

The waist-to-hip ratio offers particular insight into health-related body composition changes

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: a systematic review