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Table 4 presents the results for the changes in weight observed in Studies 1, 2, and 3

"Findings were neutral, but less precise for specific subtypes of thyroid cancer, including medullary thyroid cancer, and robust in several additional analyses, including when an alternative comparator group was used," the authors write

The large heterogeneity for some outcomes, such as CAD, may suggest different mechanisms underlying the genetic associations or the existence of pleiotropy [37]

Simple nutrition and hydration measures substantially reduce side-effect burden: roughly 70% of patients report early nausea when starting semaglutide, and about 50% report fewer side effects after diet and fluid adjustments