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Nutr Res Pract (2018) 12:101

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Through characterization of the NNTTR species in human plasma, we recently demonstrated that its formation is strongly dependent on a non-native disulfide bond formed between Cys10 on two TTR subunits within the tetramer [22]

Moreover, the observed discrepancy in ED degree category improvement according to IIEF-6 or PSV outcomes might be accounted by the absence of patients with baseline severe ED according to IIEF-6 score, as per exclusion criteria, along with the presence of a proportion of patients with baseline severe vasculogenic ED, which were included in the study based on their baseline mildmoderate or moderate ED at IIEF-6 score, as per inclusion criteria