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After 60, several critical systems are in decline simultaneously: Growth hormone (GH) secretion drops significantly with age, reducing IGF-1 levels that govern muscle maintenance, fat metabolism, and tissue repair Insulin sensitivity worsens progressively, increasing metabolic syndrome risk Inflammatory signalling chronic low-grade inflammation ("inflammaging") accelerates cellular damage Sleep architecture slow-wave sleep decreases, impairing the overnight GH pulse that drives recovery Peptides that target the GH axis secretagogues like sermorelin, CJC-1295, and ipamorelin work by stimulating the pituitary to release more of your own growth hormone

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