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Examples include Roche and Zealands $5.25 billion Petrelintide co-commercialization , Regeneron and Hansohs $2 billion GLP-1/GIP plus anti-myostatin partnership , and AbbVie and Gubras $2.23 billion long-acting amylin licensing agreement

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In the context of wet age-related macular degeneration (AMD), geniposide (GEN), a GLP-1RA, is found to downregulate HB-EGF (heparin-binding epidermal growth factor) secretion from retinal pigment epithelium (RPE) cells under hypoxic conditions through the miR-145-5p/NF-B signaling axis