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In the rest of the world, berberine is just now being widely recognized for its potential effects on heart, digestive and metabolic health

Median time to the "primary endpoint" (CHF or death) was 1228 days in the pimobendan group and 766 days in the placebo group

12 , 14 , 18 , 24 While these exclusions help reduce confounding, they do not eliminate it entirely, and attributing the observed findings solely to GLP-1 RA use remains open to debate

Omeprazole, on the other hand, is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach