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3.1.2 Semaglutide: mechanistic endpoints and effect amplification in combination therapy Evidence for semaglutide tends to focus on mechanistic and tissue-distribution endpoints

Natasha Yates wishes to thank Dr Terri-Lynne South a GP, dietician, and the chair of the Royal Australian College of General Practitioners specific interest group in obesity management for providing feedback and peer review on this article.

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This triple receptor agonist targets three distinct hormonal pathways simultaneously, creating metabolic effects that single or dual agonist compounds cannot match