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C-terminal truncation of these peptide hormones results in a significant loss of affinity and non-natural modifications are necessary to increase the activity of short peptide agonists 18,19

And its automatically in so many of these articles, so ingrained

513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism

According to the policy statement of the ACMG on clinical sequencing (Green et al., 2013), it is of utmost importance to alert the patient to the possibility of such results in pretest patient discussions, clinical testing, and reporting of resultssecondary findings list most recently updated to version 3.3 (Lee K