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The disease constitutes 5-10% of diabetes, and the disease is rising as a significant clinical and public health burden globally ( Unlike type 2 diabetes mellitus, for which many drug choices are available, the only available therapy for type 1 diabetes is insulin (Sodium Glucose cotransporters inhibitors are used as adjuvant therapy for uncontrolled T1DM and a body mass index (BMI) of 27 kg/m 2 )

In addition, the secondary end points in SUSTAIN-6 included: Time from randomization to first occurrence of an expanded composite CV outcome (defined as either EAC-confirmed MACE, revascularization (coronary and peripheral), unstable angina requiring hospitalization or hospitalization for heart failure)

The article's table says both agents influence hepatic glucose output but in opposite directions: prednisone increases it while semaglutide decreases it, and the balance between them determines net glycaemic control