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A 5% reduction in body weight is considered as clinically significant threshold for weight loss success and is associated with improved quality of life and glycemic control, while weight loss greater than 1015% is more clinically effective in the control of other obesity-associated comorbidities including hypertension, obstructive sleep apnea, polycystic ovarian syndrome, and depression [30]

Iyer SS, Cheng G (2012) Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease

GLP-1s may lower the risk of death in people with obesity, breast cancer Researchers also looked at how GLP-1s affect death in people with breast cancer and obesity who are on hormonal therapy

10.1038/sj.cdd.4401793 Cell Death Differ