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Tirzepatide (sold as Mounjaro and Zepbound) is FDA approved and available now, while Retatrutide remains in Phase 3 trials with expected approval sometime between 2026 and 2027

Allergic reactions are also uncommon, but if you experience swelling of your face, lips, tongue, or throat, or trouble breathing, seek emergency care immediately

As GIP and GLP-1 exert their actions through structurally similar G protein coupled receptors, the differential mechanisms underlying preserved GLP-1, but not GIP, insulin stimulatory responses in diabetic cells have remained enigmatic

Metabolic responses and benefits of glucagon-like peptide-1 (GLP-1) receptor ligands