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It also enhances the activity of detoxification enzymes, such as glutathione S-transferases (GSTs), which conjugate toxins to Glutathione, facilitating their elimination (Lu, 2013)

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AGERAGE signaling functions as an amplifier of oxidative stress, NF-B activation, and cytokine production, thereby affecting endothelial cells, smooth muscle cells, and possibly neural structures (162, 163)