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Neurochem Res 23:108591, PMID: 9704598 Gilbert KR, Aizenman E, Reynolds IJ (1991) Oxidized glutathione modulates N -methyl-d-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons

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These findings define a previously unrecognized microbiotabutyratemTORC1ISR axis as a central driver of PBAT-MPs-induced brain injury, and suggest that restoring butyrate signaling or targeting the downstream mTORC1ISR pathway may represent a translatable strategy for preventing BMP-related neurodegeneration