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However, the large, randomized, double-blind, placebo-controlled Ranolazine Implantable Cardioverter-Defibrillator (RAID) trial in which high-risk ICD patients with ischaemic or nonischaemic cardiomyopathy were randomly assigned to ranolazine or placebo only found a non-significant 16% reduction in the primary composite outcome of VT/ventricular fibrillation or death

Marketing claims promote rapid action despite the 15-minute half-life and poor sustained efficacy documented in trials

cAMP-responsive element modulator (CREM ) trans -represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3 + CD4 CD8 T cells in health and disease

Alpha Lipoic Acid A universal antioxidant that protects against oxidative stress and amplifies glutathione activity