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Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

This warning is based on findings in rodent studies where these drugs caused thyroid C-cell tumors (medullary thyroid carcinoma) at clinically relevant exposures

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Boosts collagen production One of the most prominent benefits of GHK-Cu is its ability to stimulate fibroblasts to produce collagen, up to 70% in some studies