Regulation of PLC1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate
Alveolar fluid glutathione deficiency in patients with pulmonary edema or respiratory distress (ARDS) linked to Covid-19, has been shown to correlate with increased damage and inflammation of mediated lung cells by ROS ( Reactive Oxygen Species )
Alternative medication classes should be considered if GLP-1 therapy proves intolerable: SGLT2 inhibitors (such as dapagliflozin, empagliflozin) for type 2 diabetes, which work via a completely different mechanism and rarely cause gastrointestinal side effects DPP-4 inhibitors (such as sitagliptin, linagliptin), which enhance endogenous GLP-1 activity more gently Metformin remains first-line for type 2 diabetes, though it can also cause gastrointestinal side effects Orlistat for weight management, though this also has gastrointestinal side effects of a different nature For weight management specifically, NICE recommends a comprehensive approach including dietary modification, increased physical activity, and behavioural interventions, with or without pharmacotherapy
Finkelstein MC, Kuhn SH, Schieren H, Weissmann G, Hoffstein S
