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GLP-1RAs not only mediate the inhibition of myocardial apoptosis, but also improve cardiac energy metabolism

DAMPs also impact Kupffer cells, activating the nucleotide-binding oligomerization domain-like receptor (NLR) Family, Pyrin Domain-Containing 3 protein (NLRP3), a type of inflammasome leading to IL-1 secretion and inflammation, and pyroptosis, releasing more DAMPs and perpetuating a destructive cycle (Hammerich and Tacke, 2023)

Novo Nordisk cited concerns about Hims & Hers selling and promoting knock-off compounded GLP-1 drugs, which are more affordable versions of the popular weight loss medications

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