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A certain level of intra-islet communication is thought to exist, where the individual hormones may reach and regulate the secretion of other islet cells, either via diffusion through the interstitial fluid or via transportation by the islet microcirculation

Furthermore, while the TAC model is a robust method for simulating pressure overload-induced cardiac hypertrophy in rodents 76 , it falls short of capturing the multifaceted etiology of human cardiac disease, including genetic predispositions and susceptibility factors

We found that in wild-type mice, the prolonged fast between meals was necessary for the beneficial effects of a CR diet on metabolic health, frailty, longevity, and cognition 12

L-theanine is highly bioavailable when taken orally and actively traverses the blood-brain barrier to enhance mental acuity and attenuate stress [25, 26]